EMAIL THIS PAGE TO A FRIEND

Expert opinion on pharmacotherapy

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease.


PMID 19929708

Abstract

Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS via glial cell attenuation. This CNS-directed anti-inflammatory activity is of potential use in the treatment of multiple sclerosis, neuropathic pain, and in the improved efficacy and safety of opioids by decreasing opioid tolerance, withdrawal and reinforcement. Its suitable pharmacokinetics and generally good tolerability make it a promising potential treatment for these conditions.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

I0157
Ibudilast, ≥99% (HPLC), solid
C14 H18 N2 O