EMAIL THIS PAGE TO A FRIEND

Biochimica et biophysica acta

Sirtuin chemical mechanisms.


PMID 20132909

Abstract

Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are universally able to bind NAD(+), and activate it to effect ADP-ribosylation of cellular nucleophiles. The most commonly observed sirtuin reaction is the ADP-ribosylation of acetyllysine, which leads to NAD(+)-dependent deacetylation. Other types of ADP-ribosylation have also been observed, including protein ADP-ribosylation, NAD(+) solvolysis and ADP-ribosyltransfer to 5,6-dimethylbenzimidazole, a reaction involved in eubacterial cobalamin biosynthesis. This review broadly surveys the chemistries and chemical mechanisms of these enzymes.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D147206
5,6-Dimethylbenzimidazole, ≥99%
C9H10N2