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Ecotoxicology and environmental safety

Toxicity of trinitrotoluene to sheepshead minnows in water exposures.


PMID 20219247

Abstract

Lethal effects of trinitrotoluene (TNT) to juvenile sheepshead minnows (JSHM) (Cyprinodon variegatus) were assessed in ten-day water exposures. Ten-day median lethal concentrations (LC50s) were 2.3 and 2.5 mg L(-1), the 10-d median lethal residue value (LR50) was 26.1 micromol kg(-1) wet weight (ww), and bioconcentration factors (BCFs) ranged from 0.7 to 2.4 L kg(-1). The lethal effects of TNT and its transformation products 2-aminodinitrotoluene (2-ADNT), 2,4-diaminonitrotoluene (2,4-DANT) and trinitrobenzene (TNB) to JSHM were compared in 5-d static-renewal exposures. Nitroreduction decreased the toxicity of TNT to SHM, as the 5-d LC50 for 2-ADNT was 8.6 mg L(-1) and the lowest lethal concentration of 2,4-DANT was 50.3 mg L(-1). TNB (5-d LC50=1.2 mg L(-1)) was more toxic than TNT to SHM. The 5-d LR50s were 4.3 mg kg(-1)ww (20.4 micromol kg(-1)) for SumTNT (TNT exposure) and 54.2 mg kg(-1)ww (275.3 micromol kg(-1)) for 2-ADNT and significant mortality occurred at 47.4 mg kg(-1)ww (283.6 micromol kg(-1)). The range of BCF values was from 1.8 to 2.4, 5.6 to 8.0, and 0.6 to 0.9Lkg(-1) for TNT, 2-ADNT, and 2,4-DANT, respectively.