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Mini reviews in medicinal chemistry

Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?


PMID 20380639

Abstract

Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

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