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The Journal of steroid biochemistry and molecular biology

A short practical approach to 24R,25-dihydroxyvitamin D3.


PMID 20385233

Abstract

A synthesis of the vitamin D3 metabolite 24R,25-dihydroxyvitamin D3 (1) by Lythgoe's Wittig-Horner approach is described. The key step of the synthesis is the stereocontrolled introduction of the 24-hydroxyl group by a palladium(0)-induced [3,3]-sigmatropic rearrangement on a 22R-allylic acetate (7).

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17943
(24R)-24,25-Dihydroxyvitamin D3, ≥98% (vitamin + pre-vitamin, HPLC)
C27H44O3