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Nucleosides, nucleotides & nucleic acids

Efficient syntheses of clofarabine and gemcitabine from 2-deoxyribonolactone.


PMID 20391198

Abstract

The development of a new methodology to achieve electrophilic fluorination of triisopropylsilyl-protected 2-deoxyribonolactone has been employed to synthesize clofarabine and gemcitabine with improved synthetic efficiency versus prior synthetic methods. These studies highlight the versatility of this new methodology to obtain medically relevant 2'-fluoronucleosides.

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30957
2-Deoxy-D-ribono-1,4-lactone, ≥95% (GC)
C5H8O4