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Applied and environmental microbiology

Genetic tool development for a new host for biotechnology, the thermotolerant bacterium Bacillus coagulans.


PMID 20400555

Abstract

Bacillus coagulans has good potential as an industrial production organism for platform chemicals from renewable resources but has limited genetic tools available. Here, we present a targeted gene disruption system using the Cre-lox system, development of a LacZ reporter assay for monitoring gene transcription, and heterologous d-lactate dehydrogenase expression.