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Journal of the American Chemical Society

Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains.


PMID 20423078

Abstract

A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.