EMAIL THIS PAGE TO A FRIEND

Organic letters

Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes.


PMID 20429535

Abstract

A clean and highly efficient enantioselective addition of alpha-isocyanoacetamides to aliphatic aldehydes catalyzed by chiral phosphoric acid in the presence of MS 5 A in toluene at -40 degrees C was developed. Excellent yields (85-98%) and good to excellent enantioselectivities (up to >99% ee) were achieved.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

108448
Cyanoacetamide, 99%
C3H4N2O