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Mutation research

Genotoxic and cytotoxic effects of the formulated insecticide Aficida on Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces: Poeciliidae).


PMID 20816847

Abstract

The acute toxicity, genotoxicity, and cytotoxicity of the pirimicarb-containing commercial-formulation carbamate insecticide Aficida (50% pirimicarb) were evaluated on Cnesterodon decemmaculatus (Pisces, Poeciliidae) exposed under laboratory conditions. Micronucleus (MN) induction as well as alterations in the erythrocytes:erythroblasts ratios were employed as end-points for genotoxicity and cytotoxicity, respectively. Cr(VI) and cyclophosphamide were used as positive controls for the toxicity and geno-cytotoxicity assays, respectively. Mean values of 344.3 and 225.5mg Aficida(®)/L were determined for LC-50(24h) and LC-50(96h), respectively. In 48h-exposed fish, a MN increase was found in Aficida-treated fish in the 50-157mg/L concentration range. When fish were exposed to Aficida for 96h, only those animals treated at 50-100mg/L showed an increase in MN frequency. Cellular cytotoxicity, revealed by a decreased proportion of circulating erythrocytes and an enhancement of erythroblasts, was found after 48h of exposure in 50-157mg Aficida/L-treated fish, while, after 96h exposure, only 100-157mg Aficida/L induced the same effect. This species provides a useful experimental model for the biomonitoring of aquatic ecosystems.

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45627
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