EMAIL THIS PAGE TO A FRIEND

Journal of neuro-oncology

Knockdown of interferon-induced transmembrane proteinxa01 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells.


PMID 20838853

Abstract

Interferon-induced transmembrane proteinxa01 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinasexa09. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas.