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Bioorganic & medicinal chemistry letters

Metallocene catalyzed synthesis of fungistatic vicinal aminoalcohols under solvent free conditions.


PMID 20864345

Abstract

Group 4 and 5 metallocenes, Cp(2)TiCl(2), Cp(2)ZrCl(2) and Cp(2)VCl(2), have been evaluated as catalyst in the solvent free, room temperature, preparation of vicinal aminoalcohols. The regioselectivity of the reaction and the fungistatic activity of the prepared compounds against Botrytis cinerea and Colletotrichum gloeosporioides are discussed.

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