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Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

Intraocular tolerance to silicone oils of different specific gravities. An experimental study.


PMID 2089354

Abstract

Different methylphenylsilicone (MPS) and fluorosilicone (FS) oils having a higher specific gravity than water were investigated as vitreous replacements. Their intraocular tolerance in vitrectomized aphakic rabbit eyes was evaluated for periods of up to 4 months and compared to that of regular polydimethylsilicone oil (PDMS). Weakly fluorinated FS and weakly phenylated MPS showed a presumably toxic effect on the retina. As compared to highly fluorinated FS, highly phenylated MPS showed better intraocular tolerance; however, inflammatory reaction was slightly more extensive than in eyes filled with PDMS.