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The Journal of organic chemistry

A strategy to synthesize taxol side chain and (-)-epi cytoxazone via chiral Brønsted acid-Rh(2)(OAc)(4) co-catalyzed enantioselective three-component reactions.


PMID 20939594

Abstract

A new approach to synthesize optically active β-amino-α-hydroxyl acid derivatives via chiral Brønsted acid-Rh(2)(OAc)(4) cocatalyzed three-component reactions of diazo acetates with alcohols and imines is reported. A matched reaction system was identified to give the products in moderate diastereoselectivity and good enantioselectivity. Application of this methodology is demonstrated in the efficient synthesis of a taxol side chain and (-)-epi-cytoxazone.

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