EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

5-benzyloxytryptamine as an antagonist of TRPM8.


PMID 20965726

Abstract

5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC(50) of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity at TRPM8. The structural similarity of 5-benzyloxytryptamine to other literature TRPM8 antagonists was noted.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

B27803
5-(Benzyloxy)indole, 95%
C15H13NO
286583
5-Methoxytryptamine, 97%
C11H14N2O