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Acta crystallographica. Section D, Biological crystallography

Using neutron protein crystallography to understand enzyme mechanisms.


PMID 21041947

Abstract

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated D-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

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