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Combinatorial chemistry & high throughput screening

Parallel solution-phase synthesis of a 2-aminothiazole library including fully automated work-up.


PMID 21118081

Abstract

A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.

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123129
2-Aminothiazole, 97%
C3H4N2S