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The Journal of organic chemistry

Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone.


PMID 21192736

Abstract

An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.