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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[Study on preparation and quality standard of Xueshuantong Drop Pills].


PMID 21213549

Abstract

To optimize the best technical parameters and establish the quality standard for Xueshuantong Drop Pills. Using moulding probability of drop pill as the evaluation to choose the best dropping condition. Using parallel experimentation for the choice of proportion of drug and matrix, and refrigerant; HPLC method was employed on ODS column which was used with a mobile phase of acetontrile-water, 0 min 20% A, 14 min 40% A, 15 min 60% A, 16 min 20% A. The wavelength of detexter was set at 203 nm. Drug-PEG4000 (1:2) was melt at 80 degrees C. Liquid-paraffin was refrigerated with 5 degrees C. Internal and external diameter of buretteare equal to 2.3 mm and 4. 8 mm. The linear ranges of notoginsenoside R1 ginsenoside, Rg1 and Rb1 were 0.51-4.08 +/- microg/mL, 3.75-30.00 microg/mL, 3.75-30.00 microg/mL, respectively. Their coefficients of determination (r) were all 0.9999. The moulding technics of drop pills have high finished product rate and good quality.

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