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Chemistry (Weinheim an der Bergstrasse, Germany)

Pd-NHC catalyzed conjugate addition versus the Mizoroki-Heck reaction.


PMID 21305628

Abstract

Ace of base: A catalytic system is presented that, solely by choice of the base, selectively switches between conjugate addition and the Mizoroki-Heck reaction of aryl halides with Michael acceptors (see scheme; R, R' = alkyl, aryl). For conjugate addition reactions, this avoids the preparation and use of organometallics.

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