Journal of magnetic resonance (San Diego, Calif. : 1997)

Suppression of probe background signals via B(1) field inhomogeneity.

PMID 21349751


A new approach combining a long pulse with the DEPTH sequence (Cory and Ritchey, Journal of Magnetic Resonance, 1988) greatly improves the efficiency for suppressing probe background signals arising from spinning modules. By applying a long initial excitation pulse in the DEPTH sequence, instead of a π/2 pulse, the inhomogeneous B(1) fields outside the coil can dephase the background coherence in the nutation frame. The initial long pulse and the following two consecutive EXORCYCLE π pulses function complementarily and prove most effective in removing background signals from both strong and weak B₁ fields. Experimentally, the length of the long pulse can be optimized around odd multiples of the π/2 pulse, depending on the individual probe design, to preserve signals inside the coil while minimizing those from probe hardware. This method extends the applicability of the DEPTH sequence to probes with small differences in B₁ field strength between the inside and outside of the coil, and can readily combine with well-developed double resonance experiments for quantitative measurement. In general, spin systems with weak internal interactions are required to attain efficient and uniform excitation for powder samples, and the principles to determine the applicability are discussed qualitatively in terms of the relative strength of spin interactions, r.f. power and spinning rate.

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