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The Journal of organic chemistry

Synthesis of (-)-homogalanthamine from naltrexone.


PMID 21381712

Abstract

Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5.

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188832
15-Crown-5, 98%
C10H20O5