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Chemical communications (Cambridge, England)

A readily synthesized cyclic pyrrolysine analogue for site-specific protein "click" labeling.


PMID 21387054

Abstract

A concise route was developed for the facile synthesis of a cyclic pyrrolysine analogue bearing an azide handle. Directed evolution enabled the encoding of this non-natural amino acid in both prokaryotic and eukaryotic cells, which offers a highly efficient approach for the site-specific protein labeling using click chemistry.

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