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Diasteroselective preparation of cyclopropanols using methylene bis(iodozinc).


PMID 21462964

Abstract

A diastereoselective synthesis of trans-2-substituted cyclopropanols is outlined. Bimetallic CH(2)(ZnI)(2) was found to react with α-chloroaldehydes to give cyclopropanols in yields of 64-89% and dr's ≥ 10:1. The high trans-selectivity resulted from equilibration of the cyclopropoxide intermediates.

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158429
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