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Nature chemical biology

D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.


PMID 21525873

Abstract

D-ornithine has previously been suggested to enhance the expression of pyrrolysine-containing proteins. We unexpectedly discovered that uptake of D-ornithine results in the insertion of a new amino acid, pyrroline-carboxy-lysine (Pcl) instead of the anticipated pyrrolysine (Pyl). Our feeding and biochemical studies point to specific roles of the poorly understood Pyl biosynthetic enzymes PylC and PylD in converting L-lysine and D-ornithine to Pcl and confirm intermediates in the biosynthesis of Pyl.

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O5250
D-Ornithine monohydrochloride, ~98%
C5H12N2O2 · HCl