EMAIL THIS PAGE TO A FRIEND

Organic & biomolecular chemistry

Asymmetric alkynylation of aldehydes with propiolates without high reagent loading and any additives.


PMID 21552582

Abstract

The asymmetric alkynylation of aliphatic and aromatic aldehydes with propiolates was mediated by dialkylzinc and a novel prolinol catalyst without high reagent loading and any additives, such as Ti(Oi-Pr)(4), to give the corresponding γ-hydroxy-α,β-acetylenic esters with high enantiomeric excess of up to 95%.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

186511
(S)-(+)-2-Pyrrolidinemethanol, 97%
C5H11NO
P51400
Propiolic acid, 95%
C3H2O2