Archives of disease in childhood

Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.

PMID 21596725


To evaluate the effect of presenting a recommendation in a clinical practice guideline using different grading systems to determine to what extent the system used changes the clinician's eventual response to a particular clinical question. Randomised experimental study. Clinician offices and academic settings. Paediatricians and paediatric residents in private and public practice in Mexico. Case notes of a child with diarrhoea and a question about clinician preference for using racecadotril. The same evidence was provided in a clinical recommendation but with different presentations according to the following grading systems: NICE (National Institute for Health and Clinical Excellence), SIGN (Scottish Intercollegiate Guideline Network), GRADE (Grading of Recommendations Assessment, Development and Evaluation) and CEBM (Centre for Evidence-Based Medicine, Oxford). Mean change in direction from baseline response (measured on a 10 cm visual scale and a Likert scale) and among groups. 216 subjects agreed to participate. Most participants changed their decision after reading the clinical recommendations (mean difference 0.7 cm, 95% CI 0.29 to 1.0; p<0.001). By groups, mean change (95% CI) from baseline was 0.04 (-0.68 to 0.77) for NICE, 0.31 (-0.41 to 1.05) for SIGN, 2.18 (1.48 to 2.88) for GRADE and 0.08 (-0.52 to 0.69) for CEBM (p=0.007 between groups). In a final survey, a small difference was noted regarding the clarity of the results presented with the GRADE system. The clinician's decision to use a therapy was influenced most by the GRADE system. NCT00940290.

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DL-Thiorphan, ≥98% (TLC)
Racecadotril, ≥98% (HPLC)