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Tetrahedron letters

Synthesis of C1-C20 and C21-C40 fragments of tetrafibricin.


PMID 21603053

Abstract

Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction.

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