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Bioorganic & medicinal chemistry letters

Pyridazine-derived γ-secretase modulators.


PMID 21636276

Abstract

SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.

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P57204
Pyridazine, 98%
C4H4N2