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Bioorganic & medicinal chemistry letters

Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.


PMID 21684737

Abstract

A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.

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A78608
2-Aminopyrimidine, 97%
C4H5N3