EMAIL THIS PAGE TO A FRIEND

British poultry science

Kinetic modelling and residue depletion of drugs in eggs.


PMID 21732884

Abstract

1. A physiologically-based pharmacokinetic model was developed for the purpose of describing the relationship between plasma concentration of drugs and their deposition into eggs. 2. By incorporating the physiology of egg formation into the model, the transfer of drugs into the egg albumen and yolk could be described using rate constants. 3. The model was used to describe concentrations in albumen and yolk of sulphanilamide, sulphaquinoxaline and pyrimethamine as a function of time using datasets from the literature. 4. The model could be used as a tool to obtain an insight into those properties of a drug which are responsible for the amount of residue in eggs, and could help in the design of critical studies for determining withdrawal periods for eggs.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

45662
Sulfaquinoxaline, PESTANAL®, analytical standard
C14H12N4O2S