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Chemical communications (Cambridge, England)

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.


PMID 21738918

Abstract

Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.

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