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Bioorganic & medicinal chemistry

LuxR dependent quorum sensing inhibition by N,N'-disubstituted imidazolium salts.


PMID 21782453

Abstract

Thirty N,N'-disubstituted imidazolium salts have been synthesized and evaluated as LuxR antagonists. Substitution on one of the imidazolium nitrogen atoms includes benzhydryl, fluorenyl or cyclopentyl substituent, and alkyl chains of various lengths on the second one. Most of these compounds displayed antagonist activity, with IC(50) reaching the micromolar range for the most active ones. The disubstituted imidazolium scaffold is thus shown to be a new pertinent pharmacophore in the field of AHL dependent QS inhibition.

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C3930
Calmidazolium chloride, solid
C31H23Cl7N2O