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Clinical pharmacology and therapeutics

Improving the use of allopurinol in chronic gout: monitoring oxypurinol levels to guide therapy.


PMID 21862966

Abstract

Urate-lowering therapy (ULT), adjusted to achieve and maintain a serum uric acid (SUA) of <6 mg/dl, remains the standard of care for the chronic management of gout. New urate-lowering medications are important options; however, these agents should be reserved for patients who do not tolerate or cannot achieve SUA <6 mg/dl on allopurinol. The result of oxypurinol monitoring to guide allopurinol therapy suggests that allopurinol should still be considered first-line ULT for gout.

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O6881
Oxypurinol, ≥98% (HPLC)
C5H4N4O2