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Bioorganic & medicinal chemistry letters

Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.


PMID 21865041

Abstract

A convenient synthesis of ketamine metabolite dehydronorketamine-d(4), starting from commercially available deuterium labeled bromochlorobenzene, was achieved. Key steps include Grignard reaction, regioselective hydroxybromination, Staudinger reduction, and dehydrohalogenation.