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Journal of medicinal chemistry

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).


PMID 21866890

Abstract

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC and a divalent metal ion was clarified by X-ray analysis. Pilot experiments have demonstrated in vivo potential.

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F8682
Fosmidomycin sodium salt hydrate, ≥95% (NMR)
C4H10NO5P · xNa+ · yH2O