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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[Preparation and pharmaceutical characterization of Marine-SSL].


PMID 21954568

Abstract

To prepare and characterize marine sterically stabilized liposomes (Marine-SSL). Liposomes were prepared by ethanol injection technique. An orthogonal test was utilized to optimize the formulation and preparation of Marine-SSL The unencapsulated marine and liposomes were separated by sephadex gel G-50, the encapsulation efficiency was detected by HPLC. The morphological examination of Marine-SSL was performed using transmission electron microscopy. The particle size and Zeta potential of the liposomes were measured. The in vitro release rate of marine from liposomes was tested. The liposomes with spherical or ellipsoidal shape and better stability featured the encapsulation efficiency of (85.39 +/- 1.21)%, the mean partical size of (156 +/- 10) nm, and Zeta potential of (- 39.0 +/- 3.06) mv. The release kinetics in vitro obeyed Higuchi equation. The stability of Marine-SSL was better. The selected formulation and preparation technic of Marine-SSL are rational and stable and liposomes feature a sustained release in vitro.

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