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Bioorganic & medicinal chemistry letters

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.


PMID 21974952

Abstract

The synthesis, evaluation, and structure-activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal and P-gp deficient mice is compared with data generated in normal rats.

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