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The Journal of antibiotics

Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis.


PMID 21989459

Abstract

The first total synthesis of extracellular factor, "Avenolide", in Streptomyces avermitilis has been achieved using a convergent approach. The stereogenic centers in two key segments were installed using Sharpless epoxidation and dihydroxylation. This synthetic study allowed the determination of the absolute configuration of avenolide as 4S,10R, and yielded important information on its structure-activity relationship.

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