EMAIL THIS PAGE TO A FRIEND

Endocrine

Estradiol-17β modulates dose-dependently hypothalamic tyrosine hydroxylase activity inhibited by α-methylparatyrosine in the catfish Heteropneustes fossilis.


PMID 21994011

Abstract

The brain is a target for organizational and activational effects of oestrogens synthesized de novo or transported from the peripheral organs. A neuroprotective role of oestrogens has been documented in a variety of vertebrates. In the present study in the catfish Heteropneustes fossilis, we have demonstrated that estradiol-17β (E(2)), the major circulating oestrogen at low dosages (0.05 and 0.1 μg/g body weight of fish for 3 days) stimulated hypothalamic tyrosine hydroxylase (TH) activity, and countered the negative effects of ovariectomy (3-week) or α-methylparatyrosine (α-MPT: 250 μg/g body weight, a competitive inhibitor of TH). In contrast, high dosages of E(2) (1 and 2 μg/g body weight of fish for 3 days) were inhibitory and further amplified the inhibitory effects of ovariectomy and α-MPT. The inhibiting role of E(2) was higher in gonad-active (prespawning) phase than gonad-inactive (resting phase) phase. The dual roles of E(2) may ensure a tight regulation of catecholaminergic activity, activating and inhibiting the system against wide fluctuations that are characteristic of seasonally breeding animals.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

120693
α-Methyl-DL-tyrosine, 98%
C10H13NO3
M8131
α-Methyl-L-tyrosine, ≥98% (TLC)
C10H13NO3