EMAIL THIS PAGE TO A FRIEND

Antimicrobial agents and chemotherapy

Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.


PMID 22106218

Abstract

Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances the growth-inhibitory effects of ethionamide, isoxyl, and thiacetazone in Mycobacterium tuberculosis strains with resistance to ETH due to inhA promoter mutations but not ethA mutations.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

E6005
Ethionamide
C8H10N2S
31056
N-Phenylthiourea, PESTANAL®, analytical standard
C7H8N2S