EMAIL THIS PAGE TO A FRIEND

Organic letters

Copper-catalyzed [5+1] annulation of 2-ethynylanilines with an N,O-acetal leading to construction of quinoline derivatives.


PMID 22276849

Abstract

A novel copper-catalyzed [5 + 1] annulation of 2-ethynylanilines with an N,O-acetal, which functioned as a C1 part, leading to the preparation of quinoline derivatives with an ester substituent on the 2-position is described. A combination of CuBr(2) and trifluoroacetic acid (TFA) promoting [5 + 1] annulation of the 2-ethynylaniline with ethyl glyoxylate is also demonstrated.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

260150
Glyoxylic acid solution, 50 wt. % in H2O
C2H2O3