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Organic & biomolecular chemistry

2-Aminopyrimidine as a novel scaffold for biofilm modulation.


PMID 22301774

Abstract

An efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Subsequent biofilm screening has allowed comparison between the biological activity of these new derivatives and that of the 2-aminoimidazole class of anti-biofilm compounds. Several derivatives displayed the ability to modulate bacterial biofilm formation, exhibiting greater activity against Gram-positive strains than Gram-negative strains. Additionally some 2-aminopyrmidines were able to suppress MRSA resistance to conventional antibiotics.

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A78608
2-Aminopyrimidine, 97%
C4H5N3