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Clinical cancer research : an official journal of the American Association for Cancer Research

Imaging tumor sensitivity to a bioreductive prodrug: two for the price of one!


PMID 22317761

Abstract

Hypoxia is an important characteristic of many solid tumors and has a major negative effect on treatment response. A way to combat this effect is with drugs called "bioreductive prodrugs" or "hypoxic cytotoxins," which are metabolized under hypoxia to toxic species. However, the patients with hypoxic tumors need to be identified.