RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Liver iron content determined by MRI: spin-echo vs. gradient-echo.

PMID 22351500


Liver iron content (LIC) measurement plays a central role in the management of patients with transfusional iron overload. Calculating the LIC with data obtained from standardized MRI sequences represents an attractive alternative diagnostic possibility. The purpose of this study was to compare the LIC measurement obtained with gradient-echo (GRE) sequences to the mean liver proton transverse relaxation (R2) acquired with SE sequences. 68 patients with iron overload (median age: 24, range: 3-88) underwent 1.5 T MRI for liver iron content measurement. All patients received spin-echo (SE) and gradient-echo (GRE) sequences. The two MRI methods revealed different liver iron content results although a significant correlation was found (r=0.85, p<0.001). Values evaluated using GRE sequences (median: 260 μmol/g dry weight [d. w.], range: 6-732) were generally higher than those obtained by SE examinations (median: 161 μmol /g d. w., range: 5-830). In conclusion, our study revealed different results for both MRI measurements, which could lead to different decisions concerning the management of chelation therapy in individual patients.