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Organic letters

Palladium-catalyzed N-arylation of 2-aminothiazoles.


PMID 22394197

Abstract

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.

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123129
2-Aminothiazole, 97%
C3H4N2S