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AAPS PharmSciTech

Physicochemical performances of indomethacin in cholesteryl cetyl carbonate liquid crystal as a transdermal dosage.


PMID 22430922

Abstract

A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC-CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1-5xa0%) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12xa0h. A low amount of IMC in 1xa0% IMC-CCC permeated the stratum corneum. Further formulation development has been carried out by the addition of lauryl alcohol into 5xa0% IMC-CCC mixture it was found that the permeation of IMC was significantly improved to 45xa0% within 24xa0h.