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Chemical communications (Cambridge, England)

One-pot synthesis of 4-substituted isoquinolinium zwitterionic salts by metal-free C-H bond activation.


PMID 22456497

Abstract

The unprecedented isoquinolinium zwitterionic salts with an unusual C-4 substitution pattern were efficiently prepared via the multicomponent reaction of in situ formed N-benzylisoquinolinium bromide with aromatic aldehydes and cyclic 1,3-dicarbonyl compounds.

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