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Organic letters

Asymmetric total synthesis and absolute stereochemistry of the neuroactive marine macrolide palmyrolide A.


PMID 22475318

Abstract

The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described. The highlight of the synthesis is macrocyclization via trans-enamide formation catalyzed by copper(I) iodide and cesium carbonate. Comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolide A.