EMAIL THIS PAGE TO A FRIEND

Organic letters

Scandium(III)-catalyzed enantioselective allylation of isatins using allylsilanes.


PMID 22506841

Abstract

The scandium(III)-catalyzed enantioselective Hosomi-Sakurai allylation of isatins with various substituted allylic silanes is described. A catalyst loading as low as 0.05 mol % is utilized at room temperature to afford the 3-allyl-3-hydroxy-2-oxindoles in excellent yields and enantioselectivity up to 99% ee, including a demonstration of a gram-scale reaction. The effects of additives and varying silyl groups were explored to demonstrate the scope and application.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

261262
Scandium, powder, 99.9% trace rare earth metals basis
Sc